Hi Kai199! I´ll answer this with a conditional 'yes', because I don't know how you use CS6: my CS6 (DVD version) works fine for my needs on my iMac running High Sierra 10.13.1, but you might want to read this thread first, which discusses one problem (bug?)...
So I was told I should still be able to launch Encore CS6 after the High Sierra update. My MBP will not open Encore. I have a full. Enjoy How To Get Adobe All Apps For free on MacOS High Sierra 2018. For MAC OS/X All files are uploaded by users like you, we can’t guarantee that How To Get Adobe All Apps For free on MacOS High Sierra 2018 For mac are up to date.
If you have your files displayed as 'free-floating' and not as tabs then closing a file will cause CS6 to crash. The post shows you how to set CS6 preferences to avoid this. I've not encountered any other problems with CS6 and High Sierra, but then I'm not really a 'power user. In some article I read removing all 11 CS6 pre-installed plug-ins was suggested. These plug-ins are found here: /Applications/Adobe Photoshop CS6/Plug-ins. It would also be a good idea to do a clean install of CS6 if you do upgrade to High Sierra. Hope this helps you! Cheers, Ian.